With our immunochemistry approach, we want to make a significant contribution to maintaining and improving patients' health. We are currently active in special areas such as dementia and liver disease, both of which are diseases with increasing prevalence.

Early detection of Alzheimer’s disease with a simple blood test

For a long time, the reliable detection of β-Amyloid was only possible from CSF or using imaging techniques (e.g. amyloid PET). Even in cases where these procedures are medically indicated, they are invasive or expensive. With the help of highly sensitive procedures such as the Sysmex HISCL immunoassay analyser, biomarkers for early detection of Alzheimer's disease - such as the β-Amyloid 1-42/ 1-40 ratio - can now be measured from blood samples. This makes diagnostics less risky, less complex and significantly more economical.

Identification of patients in the early stages of liver disease

Liver diseases kill some 300,000 people in Europe every year. Some of the biggest risk factors for liver disease are obesity, type 2 diabetes, and alcohol consumption, and as all of these are on the rise, cases of liver disease are likely to increase as well in the coming decades.

With HISCL, and our unique liver biomarker M2BPGi*, we participate in the LIVERAIM project, one of the most important initiatives to date in the chronic liver disease research field. Overall, the project s’ goal is to set up a screening platform to detect cases of liver disease early on, so that patients can take steps to protect their liver before it’s too late.

*not available in all regions

Technical specifications

Measurement Principle	Chemiluminescence Enzyme Immunoassay (CLEIA)
Dimensions / weights W x H x D [mm / kg]	HISCL-800 1,018 x 1,295 x 1,089 / 320 HISCL-5000 1,725 x 1,300 x 840 / 490
Number of Parameters Onboard	Up to 24 Parameters
Processing Capacity	HISCL-800 100 tests per hour HISCL-5000 200 test per hour
Reaction Time	Approximately 17 minutes (time from sample aspiration to to 1^st result)
Samples loading capacity	HISCL-800 up to 30 samples (6 racks x 5 samples) HISCL-5000 up to 100 samples (20 racks x 5 samples)
Number of STAT Positions	1 sample
Required Specimen Volume	10 – 30µL
Sample Container	Test tube (open)
Diameter (outer diameter):	13 – 16mm
Height:	75 – 100mm
Dead volume	150 µL
Common reagents	HISCL Line Washing Solution - Clean tubings HISCL Washing Solution - B/F separation HISCL Probe Washing Solution - Clean sample probe HISCL Substrate Reagent Set – Chemiluminescence reagents HISCL Cuvette L - Reaction cuvette HISCL Disposable Tips - Pipet tips
Reagent identification	RFID, Barcode
Reagent supply	Continiuos loading
Display (user interface)	21-inch touch screen
Data Storage	100,000 sample results (maximum)
External Output	RS232C, LAN