Today, OGT (Oxford Gene Technology) announced the launch of its newly updated NGS SureSeqTM CLL + CNV V3 Panel, which further incorporates their highly sensitive proprietary bait designs to offer more expansive coverage of disease-associated genes and enhanced CNV detection. This new panel now offers users more comprehensive variant detection to improve confidence in classification of CLL research samples to strengthen the understanding of CLL progression.
Harnessing direct input from leading clinical researchers in the field of CLL, the new panel includes an expanded list of targeted genes alongside increases in probe density allowing for higher resolution and improved tumour content estimation. Changes in reference sample processing from external to internal reference DNA reduces inter-run variability and improves confidence in CNV calls. Compared to its predecessor, the new SureSeq™ CLL + CNV V3 Panel, coupled with OGT’s complimentary NGS analysis software, Interpret, demonstrated a 38% increase in CNV detection highlighting the improved assay performance that ensures users receive the optimal experience for profiling their samples.
The SureSeqTM CLL + CNV V3 allows researchers to make more informed decisions regarding their samples, with more comprehensive variant detection and reassurance in their sample/disease classification, which is key to furthering our understanding of CLL progression. Alongside OGT’s complimentary Interpret software, users will be able to easily analyse their NGS data without the need for additional bioinformatic resource, maximising their efficiency.
“Working with leading cancer experts, including from within the ERIC Consortium, we have identified key areas for enhancement and acted upon these to develop a product that meets the demands of busy laboratories today for CLL” said Giulia Poloni, SureSeqTM Product Manager at OGT. “Combining strengthened CNV calling with expansive SNV detection gives our customers faster sample insights with reduced assay times, meaning they can speed up their lab’s sample-to-result process”.
Recent trials with this panel have demonstrated 100% detection of expected TP53 SNVs, with half of these estimated at between 1–5% VAF, additionally CNVs were confidently detected down to 20% tumour content with a 99% concordance with FISH testing.
“The CLL + CNV V3 panel is invaluable for our research as it enables us to identify key CLL-associated biomarkers”. said Anna Sobczyńska-Konefał, Head of the Department, Haemato-oncology Diagnostics, Lower Silesian Center for Oncology, Pulmonology and Haematology, Poland. “The robust technical support provided by OGT makes the panel accessible to users with varying levels of expertise in molecular techniques. Additionally, the integration with bioinformatics software simplifies the data analysis process, providing clear and actionable results.”
Carlos Martínez Pons, Head of Sysmex Life Science EMEA: “This new product strengthens Sysmex Life Science’s aim to provide the labs with the best tools for the genetic characterisation of haemato-oncological samples. The use of SureSeqTM and Cytocell ® products can facilitate the understanding of blood cancer genetics, ultimately improving the management of patients suffering these malignancies.”
For more information about the SureSeqTM CLL + CNV V3 Panel and OGT's genomics solutions, please visit our website.
About OGT
OGT, a Sysmex Group company, is a leading global provider of clinical and diagnostic genomic solutions that are created for scientists by scientists - including CytoCell®, CytoSure® and SureSeqTM ranges of FISH, microarray and NGS products. The company is dedicated to creating products that enable researchers and clinical decision makers to reach the right care decisions for each patient, every time. OGT strives to unlock the future of genetic clinical care with a commitment to working in partnership with its customers - not only by sharing its expertise of 25 years at the forefront of genetic endeavour, but also by working closely with scientists to understand their unique challenges, and to customise its approach to meet their exact needs. Dedicated to improving clinical care, OGT believes that through partnership—together—we’ll achieve more.
For more information on the Company, please visit our website at www.ogt.com.
About Sysmex Europe Life Science
Sysmex supports healthcare professionals and patients around the world with a broad range of medical diagnostics products and solutions in a variety of fields. Our multi-functional solutions work together with high-quality reagents and reliable service and support to create a better healthcare journey for all. In the field of life science, we have an ever-growing portfolio of solutions used throughout the pathway of cancer care in prevention, detection, diagnosis and monitoring. The mission is to support pathologists and oncologists by delivering essential genetic information, as quickly as possible.
Sysmex Europe SE, located near Hamburg, Germany, is a subsidiary of the Sysmex Corporation from Kobe, Japan. From our Hamburg offices, we serve our affiliates, distributors and customers throughout Europe, the Middle East, and Africa (EMEA). For more information, visit www.sysmex-europe.com.
About Sysmex Corporation
Sysmex Corporation, headquartered in Kobe, Japan, is a global leader in in vitro diagnostics. Since its foundation in 1968, Sysmex has focused on diagnostics as the core of its business, and today, it supports the health of people in over 190 countries and regions worldwide. Sysmex continues to innovate in diagnostics, and to collaboratively create unique values in the areas of personalized medicine and novel treatments, under its long-term vision of "Together for a better healthcare journey." Through its unique technology, solutions, and co-creation with various partners, Sysmex delivers new value and addresses the universal desire of people to live longer and healthier lives. The company employs more than 10,000 employees worldwide. Sysmex Corporation is listed in the Prime Market on the Tokyo Stock Exchange.
For more information about Sysmex Corporation and its affiliate companies, please visit www.sysmex.co.jp/en/.
CytoSure®, SureSeqTM and myProbes®: For Research Use Only, not for use in diagnostic procedures. CytoCell®: Some products may not be available in your region.
