Scientific documents library

Haemostasis is the biological balance between clotting and bleeding. A deficiency of any clotting factor will shift this balance towards a bleeding tendency.

The study found that the cloning of Sysmex XF-1600 instrument settings, combined with a common panel and common analysis template, resulted in comparable results across three different sites when using stabilised PNH material tested in combination with the Exbio DryFlowEx PNH High-Sensitivity Assay Kit.

Urinary tract infections (UTI) belong to the most common bacterial infections and, though suspected cases often turn out to be negative, contribute to high laboratory workloads and empiric prescription of antibiotics, a main driver antimicrobial resistance (AMR). This white paper reviews the strengths of the UF-series in ruling-out UTI, supporting its diagnosis and potential applications to further optimise the UTI laboratory workflow, aiming to fight AMR.

Diagnostics play a major role in the rational prescription of antibiotics. Well-known antimicrobial susceptibility tests (AST) are reliable tools for the phenotypic determination of resistance to antibiotics [6]. Several solutions to support AST performance are available on the market.

Despite the tremendous technological advancements in optimal detection and classification of different types of blood cells, there are still some rare cases where spurious results can emerge due to certain interfering factors. The focus of this SEED article series is to present the potential root causes of some well-characterised special patterns that result in spurious results on the Sysmex 5-part differential haematology analysers, explain which reportable parameters might be affected and highlight aspects of scattergrams and flagging that can support the prompt identification of these patterns.

This case study explains how the same lymphocytes react in two different complementary methods: fluorescence flow cytometry in the WPC channel of the XN-Series haematology analyser and multicolour immunophenotyping using the XF-1600 analyser. The haematology analyser detected a lymphocytosis and a suspect flag for ‘Abnormal Lympho?’. Subsequently, clinical flow cytometry was performed and the markers confirmed the diagnosis of a B-CLL in this patient.

The evaluation of the effectiveness of antiplatelet medication and forecast of future cardiovascular complications are very important for many patients. The immature platelets are more reactive compared to mature platelets and have a higher prothrombotic potential. IPF# can be associated with poor antiplatelet drug response due to residual platelet reactivity and has been shown to have additional value compared to traditional platelet function tests. In this white paper the related scientific publications are explained.