Scientific documents library

The fluorescence technology and channel-specific reagents of the XN-Series provide much more than just a cell count. Depending on their cell membrane composition, cells are perforated and labelled differently, disclosing information about the cells’ activity, maturity stage, and malignancy. This white paper sheds a light on how the XN measures cell functionality.

In 2020, the Scientific and Standardization Committee of the ISTH published an update of the guideline for lupus anticoagulant detection and interpretation. The innovations and changes that this guideline brings with it are summarised in this white paper.

Once the analysis results have been technically validated and considered reliable, they can be looked at from a clinical angle to search for suspect results. The task of biomedical validation is to recognise abnormal or conspicuous quantitative results. Based on the findings compiled by the GFHC, there is a new rule set implemented in Extended IPU looking at things such as cut-off values, assessment of previous values or additional patient information. Check out the recommendation from GFHC.

Haematopoiesis is the process by which uncommitted haematopoietic stem cells proliferate and differentiate into all the cellular components of the blood.

This clinical information card addresses the clinical challenges during haematopoietic stem cell transplantation (HSCT) treatment. The example case of an oncologic patient is described and the benefits of advanced clinical parameters delivered by the haematology analysers are emphasised for all phases of the HSCT treatment: mobilisation, chemotherapy and engraftment.

The first part of this SEED article informs about haematopoietic stem cells, their aetiology and sources as well as the clinical background of haematopoietic stem cell transplantation (HSCT).

The second part of the SEED article explains in detail the process of HSCT with its phases and requirements.

In this case report laboratory results of a two-year-old patient presented at the hospital with watery stool (later bloody stool with fever appearing) are shown. The CBC measured on XR-Series showed leucocytosis, anaemia, thrombocytopenia and schistocytes. Further test results revealed acute kidney injury, elevated lactate dehydrogenase (LD), an increase in C-reactive protein (CRP) and antibodies to Escherichia coli O157 lipopolysaccharide were found as well. This led to the suspicion of haemolytic uraemic syndrome due to Shiga toxin-producing E. coli.

What you always wanted to know about haemophilia can be found in this SEED. Starting with what haemophilia actually is, this article outlines the cause, effects and late effects, as well as former and current treatment methods. The reader will also receive guidance on the laboratory diagnosis of haemophilia A and B, as well as on the detection of anti-factor VIII antibodies.